Brainy Quote of the Day

Showing posts with label #Ebola. Show all posts
Showing posts with label #Ebola. Show all posts

Tuesday, February 17, 2015

But a Whimper...

Image Source: Technology Review
Topics: Ebola, Biology, Mathematical Models, R0 ("r naught"), Research, STEM

This is the way the world ends
This is the way the world ends
This is the way the world ends
Not with a bang but a whimper.

The last, easily remembered and often quoted stanza of T.S. Elliot's poem "The Hollow Men." It bears reading (link provided) in light of current events.

A simple search on this site for Ebola will likely now bring up this article and others written during the faux panic. Due to the "medical expertise" of now infamous anti-vaccination activists (who have been previously mentioned), measles has made a resurgence, and if not shut down, at least exacerbated the profits of the Magic Kingdom.

Presented here is what will likely not make the local or national news with exception of braver souls that take their duty to inform (not entertain) the citizenry seriously over the altar sacrifice to the Moloch of Nielsen:

TECHNOLOGY REVIEW: On March 17, 2014, doctors diagnosed a single case of Ebola in the county of Lofa in Liberia, West Africa. This was the first, patient zero, in an epidemic that has so far infected more than 20,000 people and killed almost 8000.

On August 15, the World Health Organization and other bodies began a major drive in Liberia to halt the epidemic. The strategy has two parts. The first aims to limit the spread of the disease from people who have been infected by ensuring that everyone with symptoms goes to an official treatment center.

The second is to prevent the spread of the disease after death by ensuring that every Ebola victim is buried in a way that prevents further infection. That means wearing protective clothing to place the body in a body bag and then in a coffin before transporting it to a grave. Finally, the aid workers must disinfect the victim’s home and ensure appropriate washing for all those involved in the disposal of the body.

Together, these measures appear to have had a significant effect on the spread of the disease. But an important question remains: when will the epidemic end?

Today, we get an answer thanks to the work of Lucas Valdez from the National University of Mar del Plata in Argentina and a few pals. These guys have created a mathematical model of the way the disease spreads that predicts an end to the epidemic for the first time.

Abstract
The Ebola virus is spreading throughout West Africa, causing thousands of deaths. When developing strategies to slow or halt the epidemic, mathematical models that reproduce the spread of this virus are essential for understanding which variables are relevant. We study the propagation of the Ebola virus through Liberia by using a model in which people travel from one county to another in order to quantify the effectiveness of different strategies. For the initial months in which the Ebola virus spreads, we find that the arrival times of the disease into the counties predicted by our model are in good agreement with World Health Organization data. We also find that reducing mobility delays the arrival of Ebola virus in each county by only a few weeks, and as a consequence, is insufficient to contain the epidemic. Finally we study the effect of a strategy focused on increasing safe burials and hospitalization under two scenarios: (i) one implemented in mid-July 2014 and (ii) one in mid-August, which was the actual time that strong interventions began in Liberia. We find that if scenario (i) had been pursued the lifetime of the epidemic would have been reduced by three months and the total number of infected individuals reduced by 80\%, when compared to scenario (ii). Our projection under scenario (ii) is that the spreading will cease by mid-spring 2015.

Physics arXiv: Predicting the extinction of Ebola spreading in Liberia due to mitigation strategies
L. D. Valdez, H. H. A. RĂªgo, H. E. Stanley, L. A. Braunstein

Saturday, November 1, 2014

Strategies for Containing Ebola...

ABSTRACT
The ongoing Ebola outbreak poses an alarming risk to the countries of West Africa and beyond. To assess the effectiveness of containment strategies, we developed a stochastic model of Ebola transmission between and within the general community, hospitals, and funerals, calibrated to incidence data from Liberia. We find that a combined approach of case isolation, contact tracing with quarantine and sanitary funeral practices must be implemented with utmost urgency in order to reverse the growth of the outbreak. Under status quo intervention, our projections indicate that the Ebola outbreak will continue to spread, generating a predicted 224 (95% CI: 134 – 358) cases daily in Liberia alone by December, highlighting the need for swift application of multifaceted control interventions.

Science:
EBOLA EPIDEMIOLOGY
Strategies for containing Ebola in West Africa
Abhishek Pandey1,*, Katherine E. Atkins1,*, Jan Medlock2, Natasha Wenzel1, Jeffrey P. Townsend3, James E. Childs4, Tolbert G. Nyenswah5, Martial L. Ndeffo-Mbah1, Alison P. Galvani1,4,†

Tomorrow: Automaton

Monday, October 27, 2014

Fear Bola and Duct Tape...


"Sell the fear": it was the instruction I received in a very uneventfully short career as a sales representative for an electronics security firm. Part of the memorized script I recited that entailed sharing horrid crime stats to wearied prospective buyers was "how did that make you feel?" It was of course, supposed to make you feel afraid, very afraid...for your lives and reaching for your checkbooks. At an appointment scheduled through the office, before I could launch into my memorized banter, the woman said: "I was just burglarized last night." Undoubtedly, the fastest sale I ever had. She knew exactly how she felt: violated, angry and afraid.

It is interesting then, that this definition is put forth. All the networks do this: posing simultaneously as the voice of reason and prophets of doom. It looks for answers while promoting doubt post "X-Files" that the "truth is out there." It makes a rational discussion and discourse almost impossible to attain.

This fear is unfortunately the byproduct of 9-11, reminiscent of the fear of Anthrax attacks that spurred the prodigious purchases of duct tape (I'm sure like manufacturers appreciated the bump in sales). Currently, a mint is being made in HAZMAT suits and other emergency supplies, just in time for Halloween. The governors of Illinois, New Jersey and New York are now competing in the silly season on which can suspend the Civil Rights of medical professionals the fastest, NJ and NY's main men potential presidential candidates in 2016, but I'm sure that has nothing to do with it. Both have used the now bipartisan, feckless dodge "I'm not a scientist" to defend inaction on climate change and fracking (NJ's chief executive selective ignorance notable after the devastation of Hurricane Sandy and his previous complaints of congressional inaction).

The danger of these draconian measures will be eventually discouraging military and medical professionals from doing what we did after 9-11 (paraphrase): "fighting terrorists/Ebola over there before they/it comes over here." What nurse or doctor will WANT to volunteer for hazardous duty when instead of a hero's welcome, they get thrown in a gulag? Kaci Hickox has tested negative, NEGATIVE for Ebola 2X! The protocol for self monitoring has worked successfully since developed for dozens of volunteers that have come to our shores after duty since 1976, when the virus was first reported on the continent of Africa. Nina Pham (RN), Amber Vinson (RN) both of Texas Presbyterian and Doctor Craig Spencer are medical professionals that knew these protocols and reacted to them swiftly. Could they be tightened? I'm for lowering the standard of the 103 degree temperature to any low-grade fever when you've deployed to an affected area along with the self-monitoring/isolation and reporting to medical authorities when anything changes. Ms. Vinson was diagnosed with a low-grade fever of 99.5 degrees after travel, and not infectious (a TV host in New York got explicitly graphic on the unlikelihood of casual infection). It does appear catching the infection prior to any forthcoming vaccine early is the key to survival.

The problem with this lack of appreciation for STEM fields, atomizing humanity to islands of xenophobia in our Solar System's outer asteroid belt (a mythical "over there" that will magically not affect us); tying the hands and feet that must combat Ebola [actually] "over there" that will tragically affect us, the inevitable outcome is the very thing no one wants: a modern plague, first in Europe then in America. We will fair better as currently not being torn asunder by Civil War (imagine the impact if this struck us during our actual Civil War). As a nation, we seem determined to do the stupid, and swiftly.

Thursday, October 23, 2014

Apps and Ebola...

Technology Review
Perhaps the sanest proposal I've heard so far, using technology to get people to the necessary treatment, track patients accurately; contain and control a pathogen before its R0 of 2 out of apathy based on xenophobia and tribalism grows exponentially to Bubonic proportions. With this country's current disastrous love affair with austerity, I'm not talking about the ubiquitous "there"...

"We live in a society exquisitely dependent on science and technology, in which hardly anyone knows anything about science and technology." Carl Sagan.

Nigeria is Ebola free...so is Senegal, largely due to both countries having enough infrastructure and concerted effort to combat it, proving it can be contained and conquered. Thomas Eric Duncan has died, and two nurses that worked his case have been affected and are receiving the best treatment available. But, we've been exquisitely conditioned via initially pamphlets, chat rooms, talk radio and the Internet to not trust the government or technology - the moon landing never happened; a stateless cabal rigs every election to their desired outcome, not voter apathy, suppression-cum-"integrity" or Supreme Court judicial activism; "jack-booted thugs" will come, in black helicopters to intern us all in FEMA camps taking our guns and freedoms. The wondrous beauty of most conspiracy theories is they never have to be proven, and actual plots can be conveniently ignored.


In this election season especially, fear must be sold from those with no other plan than to just be afraid; Nigeria and Senegal's good news you'd never have known.


TECHNOLOGY REVIEW: Back in July, Cedric Moro started a crowdsourced mapping service to keep track of the spread of Ebola in Sierra Leone, Liberia and Guinea. Moro is a risk consultant who has created several crowdsourced maps of this kind using the openStreetMap project Umap.


Anyone can enter information about suspected or confirmed Ebola cases while hospitals and other health facilities can tell people whether they are open and functioning and how many spare beds they have.


The site tracks other information to such as unsafe burials, hostility towards health workers and links to information about the disease. It even tracks the movement of infected individuals to see how the disease spreads.


Moro’s work has been hugely important in helping to link potential victims with appropriate healthcare facilities and giving a broader overview of the tragedy as it unfolds.


But it also has an important limitation. Anyone hoping to contribute must have access to a computer or smartphone to upload their information. That means the system is accessible only to a relatively small portion of the population.


Today, Mohamad Trad from Doctors Without Borders in Paris, France, and a couple of pals outline plans to build on Moro’s approach and make this kind of information available purely through ordinary mobile phones. “We propose building a recommendation system based on simple SMS text messaging to help Ebola patients readily find the closest health service with available and appropriate resources,” they say.


Abstract


We propose to utilize mobile phone technology as a vehicle for people to report their symptoms and to receive immediate feedback about the health services readily available, and for predicting spatial disease outbreak risk. Once symptoms are extracted from the patients text message, they undergo complex classification, pattern matching and prediction to recommend the nearest suitable health service. The added benefit of this approach is that it enables health care facilities to anticipate arrival of new potential Ebola cases.

arXiv:
Guiding Ebola Patients to Suitable Health Facilities: An SMS-based Approach

Mohamad Trad, Raja Jurdak, Rajib Rana

Related link:
World Science Festival: Everything You Need to Know About Ebola