Brainy Quote of the Day

Saturday, September 21, 2013

Luis Federico Leloir...

The Nobel Prize in Chemistry 1970
Luis Leloir

Luis F. Leloir

Born: 6 September 1906, Paris, France

Died: 2 December 1987, Buenos Aires, Argentina

Affiliation at the time of the award: Institute for Biochemical Research, Buenos Aires, Argentina

Prize motivation: "for his discovery of sugar nucleotides and their role in the biosynthesis of carbohydrates"

Field: Biochemistry

Luis F. Leloir was born in Paris of Argentine parents on September 6, 1906 and has lived in Buenos Aires since he was two years old. He graduated as a Medical Doctor in the University of Buenos Aires in 1932 and started his scientific career at the Institute of Physiology working with Professor Bernardo A. Houssay on the role of the adrenalin carbohydrate metabolism. In 1936 he worked at the Biochemical Laboratory of Cambridge, England, which was directed by Sir Frederick Gowland Hopkins. There he collaborated with Malcom Dixon, N.L. Edson and D.E. Green. On returning to Buenos Aires he worked with J.M. Muñoz on the oxidation of fatty acids in liver, and also together with E. Braun Menéndez, J.C. Fasciolo and A.C. Taquini on the formation of angiotensin. In 1944 he was Research Assistant in Dr. Carl F. Cori's laboratory in St. Louis, United States and thereafter worked with D.E. Green in the College of Physicians and Surgeons, Columbia University, New York. Since then he has been Director of the Instituto de Investigaciones Bioquímicas, Fundación Campomar. With his early collaborators, Ranwel Caputto, Carlos E. Cardini, Raúl Trucco and Alejandro C. Paladini work was started on the metabolism of galactose which led to the isolation of glucose 1,6-diphosphate and uridine diphosphate glucose. The latter substance was then found to act as glucose donor in the synthesis of trehalose (with Enrico Cabib, 1953 ) and sucrose (with Carlos E. Cardini and J.Chiriboga, 1955). Other sugar nucleotides such as uridine diphosphate acetylglucosamine and guanosine diphosphate mannose were also isolated. Further work showed that uridine diphosphate glucose is involved in glycogen synthesis and adenosine diphosphate glucose in that of starch.

Nobel Prize:

Biographical, Nobel Lecture, Banquet Speech

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